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Patients assigned to tirzepatide showed a 20.9% BW loss after 36 weeks with an additional 5.5% reduction after 52 weeks, while those who switched to placebo experienced a 14% weight regain, confirming the findings from STEP 4 supporting the chronicity of obesity and the need for continuous treatment

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Based on the current findings, a fixed amount of 300 mg SNAC was chosen for all dose strengths of semaglutide for further clinical development

Available online at: (Accessed February 10, 2025)