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In hypertension, it may be that low NO levels result in reduced expression of CSE with a subsequent decrease in H 2 S production, lowering plasma concentrations and increasing vascular contraction

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Impaired Detoxification : Without adequate glutathione, the body struggles to detoxify effectively, leading to the accumulation of harmful substances

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Values above 3 ULN with symptoms, or above 5 ULN at any time, are the thresholds at which the monitoring protocol calls for pausing the drug