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We're losing muscle and now our metabolism is shifting and our ability to control our blood sugar is shifting as well

J Pineal Res 34:4052 Jaworek J, Nawrot K, Konturek SJ, Leja-Szpak A, Thor P, Pawlik WW (2004) Melatonin and its precursor, L-tryptophan: influence on pancreatic amylase secretion in vivo and in vitro

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I expect that there will be at least one arm of the phase 3 trials Lilly will run, and I suspect they may also try a 12mg arm and probably a 6mg arm as they tend to aim for 3 approved doses for weight loss indications