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doi: 10.1042/bsr20182192 204 Abo ElAttaASAliYBMBassyouniIHTalaatRM
GCL, heterodimer made up of the heavy sub unit (73 kDa) has the catalytic activity (GCLC), and is the site of GSH feed back inhibition The light (30 kDa) or modifier (GCLM) sub unit, alter, or regulate the activity of the holoenzyme Glutamate cysteine ligase (GCL) L-glutamate + L-cysteine + ATP -L-glutamyl-L-cysteine + ADP + Pi GCL is regultate physiologically by : Feed back competitive inhibition by GSH The availability of its precurser, L-cysteine
Who Should Be Cautious: Patients with a history of pancreatitis or gallbladder disease should discuss these conditions with their provider before starting either medication
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