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Based on the sampling site of healthy subjects, dental samples showed separate cluster in both BrayCurtis (PERMANOVA, R 2 = 0.0674, p-value = 0.001, Figure 1E ) and unweighted UniFrac distance (PERMANOVA, R 2 = 0.0388, p-value = 0.001, Supplementary Figure S2C ) analysis
Individuals on certain medications or with health conditions like high blood pressure, heart disease, or a history of seizures should consult a healthcare provider before using nicotine gum
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Pipe Tobacco: Often uses Virginia, Burley, and Oriental tobaccos in various proportions to create complex flavors
it constantly irritates the gums and causes them to inflame, resulting in periodontal disease
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