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Managing Side Effects During Tirzepatide Dose Escalation Gastrointestinal effectsincluding nausea, vomiting, and constipationare the most common side effects during tirzepatide titration, occurring in 2540% of patients but typically diminishing after 48 weeks of consistent dosing

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Retatrutides 48-week data may not represent the compounds maximum potential, while longer Mazdutide studies continue generating data

However, this mechanism also slows down the process of moving food through your intestines, sometimes resulting in constipation while your body adjusts to the medication