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IGF-1 DES has a shorter half-life and more localized effect, which means it carries less systemic risk but more site-specific irritation
Management: Rotate sites, use smaller insulin syringes, and keep injection volume low (0.5 mL) Potential for IGF-1 Resistance or Downregulation Using IGF1 LR3 continuously without breaks can desensitize IGF1 receptors , reducing effectiveness over time
Given that cellular senescence is now recognized as one of the primary pillars of biological aging, this third mechanism elevates MOTS-c from a metabolic peptide to a potential geroscience intervention
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