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In contrast to their expectations, the results have shown that daily supplementation with vitamin C and vitamin A for 4 weeks not only failed to improve the insulin responsiveness but also decreased the expression of ROS-sensitive transcriptional regulators, molecular mediators of ROS defense (SOD 1 and 2, glutathione peroxidase) [90]
Xu et al., 2019
When you swallow that expensive multivitamin, your digestive tract acts like a picky bouncer, only letting about 20-30% of the nutrients through
Plus, salicylic acid is drying
Considering the recent X-ray crystallography and cryo-EM data, which revealed that GSH and Glu could bind to different domains of GLR3.4 for ion channel activation 30 , it would be intriguing to investigate whether GSH binds to GLR3.3 and further determine the potential relationship between GSH and Glu in activating GLR3.3
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