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We recently showed that AFB 1 and AFM 1 at picomolar concentrations could further affect the metabolic pathways by inhibiting insulin production in pancreatic islets in vitro (92)

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Particularly, genes involved in lipid metabolism ( Abcg5 ), drug metabolism ( Cyp2a4 ), GSH metabolism ( Gstm2 and Gstm6 ), and oxidative phosphorylation ( Lhpp ) were expressed at higher levels in the liver of hepsin / mice compared with wild-type mice

Mehrere experimentelle Modelle deuten darauf hin, dass das Peptid die zellulre Widerstandsfhigkeit ber antioxidative Mechanismen untersttzen knnte

doi: 10.1038/s41392-024-01931-z 23