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The low GSH concentration necessary for CVA21 displacement may also limit a co-elution of potentially bound host cell GST enzymes present in cell culture harvests, which may require as high as 10 mM GSH for elution (Figure 4A) and elution NaCl gradient (Supplementary Figure S6C) studies where CVA21 particles eluted at lower ionic strengths with increasing pH

Similarly, peptide abundance for C1QA was significantly increased in the PCC and convalescent groups, although ELISA measurements were comparable across groups (Fig

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Bile has many important functions, one of which is the flushing of waste products from the liver our largest and most hard working detoxing organ