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Data confirmed the upregulation of Ggt1, Sepw1, and Muc1 genes in 3D spheroids and suggested that, since GGT1 provides substrates for glutathione synthesis, which is utilized as cofactor of both GPX4 and Selenoprotein W, lung CSCs may be protected from ferroptosis by the activation of a GSH-dependent antioxidant mechanism

Without GPX4 activator, the downstream metabolites of the 5-LOX, 12-LOX, and 15-LOX pathways were markedly elevated after A23187 stimulation ( Figure 4 ), compared to the normal state ( Supplementary Figure S2 )

Alcoholic liver disease: utility of animal models

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NAD IV therapy can last 414 days