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Mol Pharmacol (2014) 85(1):5061.10.1124/mol.113.088484 50 DozENoulinNBoichbtEGuenonIFickLLe BertMet alCigarette smoke-induced pulmonary inflammation is TLR4/MyD88 and IL-1R1/MyD88 signaling dependent

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These effects do not disappear unless smoking stops completely

The smoking epidemic model describes that men in high-income countries (particularly the Anglo-Saxon countries) were the first to take up smoking and that smoking-attributable mortality rose some three decades after the rise in smoking prevalence