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Erythrocytes: structural features (lack of organelles) determine the cell death signaling pathways Unlike normal nucleated cells, mature erythrocytes are hemoglobin-filled, flexible, thin nucleus- and organelle-free entities of biconcave shape with a size of 78 m [29]
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Although JNK is often linked to pro-apoptotic signaling, its effects are highly dependent on timing and context 74,75
Indeed, MetS, prevalent among obese individuals, often manifests with glucose intolerance, insulin resistance and dyslipidemia (i.e., hypertriglyceridemia and hypercholesterolemia) (Cornier et al., 2008)
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