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As between-study heterogeneity can be underestimated or even zero when the number of studies is small 196,197 , we used Fishers information matrix to estimate the uncertainty of the heterogeneity 198 and incorporated that uncertainty into the final results

This shows that smokers die of lung cancer 10 times as often ( 10.73 , above) as do nonsmokers, which is a very high relative risk

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