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As a classic ligand of the Wnt/-catenin signaling pathway, Wnt3a suppresses adipogenic differentiation of MSCs via the downregulation of peroxisome proliferator-activated receptor (PPAR) and CCAAT/enhancer-binding protein (C/EBP) (152), thereby playing a crucial role in protecting against bone loss and regulating lipid metabolism in OVX rats

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Tirzepatide and semaglutide can have the unfortunate side effect of potential muscle loss alongside their therapeutic effectsparticularly if youre on a long-term weight loss plan