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Chem Res Toxicol 1997

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THC acts on the CNR1, but cannabidiol has no psychotropic activity and acts on the 5-hydroxytryptamine 1A (5-HT1A) receptors.42 There is clinical data showing that cannabis has antiemetic properties and is frequently used by patients with CVS to alleviate the symptoms of nausea and vomiting, lack of appetite, and stress.14 Contrastingly, several case series on cannabinoid hyperemesis syndrome (CHS) have implied that the chronic use of cannabis causes vomiting.4345 Approximately 20% of patients with CHS use cannabis 4 times a week, whereas the rest are occasional users

This latter group represents the population with almost certain chronic illness risk due to their body fat composition