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If hunger persists despite these measures after 12 weeks on the full maintenance dose, contact your GP or prescribing specialist to discuss whether Saxenda is the appropriate treatment for you

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It was demonstrated that in the spinal cord of the SOD1-G93A ALS mouse model, the mitochondrial receptor SQSTM1/p62 is recruited to the mitochondrial surface, where it activates mitophagy, whereas knockdown of the Parkin gene reduces the loss of motor neurons, thereby delaying the progression of disease in SOD1-G93A mice (Palomo et al., 2018)