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We will need more detailed research to know if they can be used effectively and safely. Professor Baulds review of existing research, conducted with Massey University in New Zealand and published in the journal Nicotine and Tobacco Research, highlights the role of nicotine in speeding up the metabolism and activating brain receptors that suppress the appetite

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However, with IC50-values in the range 560-12,000 M it seems unlikely that these compounds will inhibit nicotine metabolism at the amounts used in cigarettes

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