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Acetylcholine by stimulating the 7nAChR inhibits the activity of the pro-inflammatory neurothrophic factor kappa B (NFB) in human macrophages and consequently the expression and release of cytokines such as the tumor necrosis factor (TNF) by these immune cells (Balakumar and Kaur, In rats, all dopaminergic neurons in the SNc express the 7nAChR (Yanagida et al., 2008)

Smokers who were older, age 4049 years (AOR=0.63