Its table says an empty stomach is required for oral forms, while the tolerability section suggests taking the medication with an appropriately sized meal to improve comfort
Wegovy is administered as a once-weekly subcutaneous injection, with dosing gradually escalated over 16-20 weeks to minimise gastrointestinal side effects
Streptozotocin-induced diabetes produced persistent hyperglycaemia, marked body weight loss, and impaired behavioural performance, particularly prolonged escape latencies in the Morris Water Maze and a selective short-term Passive Avoidance deficit
About 20% of patients taking the higher dose in both trials experienced this effect, compared with about 5% of those on the lower dose
The cohort was somewhat diverse: 74.9% were White, 18.2% were Black, 7.1% had Hispanic ethnicity, 1% were Asian, and 3.5% were of other races