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While it may be too early to say nicotine causes cancer, questions are being raised about how the chemical acts in non-tobacco forms like e-cigarettes and nicotine-replacement patches

For instance, histones H1, H2B, and H3 undergo nitration and oxidation by reacting with peroxynitrite, resulting in alterations to chromatin structure and genome stability (Khan et al., 2016)

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The clinical value of the intervention and its contribution to overall patient health outcomes should be weighed alongside the direct reimbursement amount