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8 Department of Respiratory Medicine, Private clinics Musumeci-Gecas, Catania, Italy *These authors contributed equally to this work Background: Health effects of electronic cigarette (EC) use in patients with chronic obstructive pulmonary disease (COPD) are largely unexplored

Progress is hindered by the confounding effects of host genetics, diet, and environment, the heterogeneity of microbial sampling and sequencing methodologies, and the limited fidelity of rodent models in recapitulating human smoking behaviors

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Roughly 30 a day for the past six years, maybe 15 a day for four years before that

Some people go to church on Sundays