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Nutt, D

titled Modulation of the Endocannabinoid System: Vulnerability Factor and New Treatment Target for Stimulant Addiction, published in Frontiers in Psychiatry (2013), polydrug use involving stimulants heightens cardiovascular strain and increases the likelihood of addiction

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Generally, the data show that the population most likely to use THS are current smokers, with low uptake by youth and nonsmokers, and a slightly higher, but still low likelihood of uptake in former smokers