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[2] Todd McCarthy of Variety called the film "dismally unfunny" and questions "if any director could have surmounted the script's limitations" and of the acting performances he says "only Garofalo and Ben Affleck manage to project any wit that cracks through the prevailing humorlessness." [4] Mick LaSalle of the San Francisco Chronicle gave it a positive review, saying " 200 Cigarettes doesn't have a bad scene or a false note

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This last cytochrome isoform, for example, plays a key role in the metabolism of widely used drugs such as theophylline, lidocaine and clozapine, but it also intervenes in the activation of certain pro-carcinogens [20]