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"These drugs would hopefully make it easier for women to quit nicotine." The researchers said that this knowledge could be particularly useful for those taking estrogen in the form of oral contraceptives or hormone replacement therapy, which might increase the risk of developing a nicotine use disorder

CRS was also employed as the control behavioral strategy in a randomized controlled trial (RCT) evaluating pharmacogenetic guided therapy versus varenicline 6

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For some, it was the drug of modernity, as its soothing effects (caused by nicotine) were the ideal antidote to the stress and tension that came with the machine age