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Of note, in our population most of this effect was driven by an increase in the late diastolic component of mitral annulus motion (Figure 5, top panels), with only a nonsignificant trend towards a reduction in the early diastolic component

Accessed 15 May 2021 Xue Y, Morris M, Ni L et al (2010) Venous plasma nicotine correlates of hormonal effects of tobacco smoking

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The majority of the tobacco smokers were males (91.3%), 66.4% of them were married, and more than two-thirds were residing in urban areas