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Finally, the Japanese experience points to the potential to achieve dramatic reductions in smoking without the planning or approval of government regulators

Second, Japan maintained a relatively large adult smoking population compared to many developed countries so there was already an established market looking for alternatives

There are approximately 600 different chemicals in a single cigarette, and burning it creates approximately 10 times more

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or (ii) The approved labeling includes the indication for use in conjunction with immunosuppressive drugs to prevent or treat rejection of a transplanted organ or tissue