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These chemicals are stored in tobacco leaves and, therefore, become part of cigarettes

In particular, CYP1A1 and 2E1, although playing a minor role in the overall metabolism, can be induced by PAHs making smokers more prone to severe ADRs (e.g., QT prolongation) due to increased metabolite concentrations

Kang HG, Kwon KH, Lee IW, Jung B, Park EC, Jang SI

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According to official reports, over 16 million Americans live with a disease caused by nicotine use