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Medical studies highlight several key reasons for tobacco-induced hair thinning: Narrows blood vessels, thereby reducing blood circulation to hair follicles Triggers DNA damage and hair follicle cell degradation Causes oxidative stress and inflammation Hampers the absorption of nutrients Accelerates premature ageing of the scalp Smoking generally exacerbates existing hair loss patterns (such as male/female pattern hair loss, or acute telogen effluvium) rather than causing total baldness on its own

One study suggested that triggering selective mitophagy may be a rescue mechanism that allows ASCs to maintain pluripotence and survive in an adverse, proinflammatory adipose tissue microenvironment

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