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An optimal prospective observational study design would identify and follow a large cohort of smokers who want to quit or are making a quit attempt, assess e-cigarette exposure in detail before the smoking cessation outcome is assessed, biochemically confirm self-reported tobacco abstinence, and adjust for multiple potential confounding factors associated with e-cigarette use and with smoking cessation

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The government's strategy has been to incrementally hike the excise of tobacco through annual increases of 12.5% from 2013 to 2020

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APP : Musahl and his collaborators came up with PIVOT, an iPad app that video records the pivot-shift test as a physician performs it