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The presence of any ABCDE feature does not automatically mean melanoma, but it does mean the spot should be evaluated by a dermatologist who can perform dermoscopy or biopsy to reach a definitive diagnosis

The intracellular domain has three portions: a juxtamembrane sequence that downregulates kinase activity which is followed by phosphorylation of Ser975 which is a catalytic region that promotes kinase activity leading to transphosphorylation of Tyr1234 and Tyr1235

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Candida albicans heat shock proteins and Hsps-associated signaling pathways as potential antifungal targets