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Advantage : Neither (tie) Weight Loss Efficacy# CagriSema : REDEFINE 1 demonstrated 20.4% mean weight loss at 68 weeks

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Doi: Costa ACS, Brando AC, Boada R, Barrionuevo VL, Taylor HG, Roth E, Stasko MR et al (2022) Safety, Efficacy, and Tolerability of Memantine for Cognitive and Adaptive Outcome Measures in Adolescents and Young Adults with Down Syndrome: A Randomised, Double-Blind, Placebo-Controlled Phase 2 Trial

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