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The study found that there was a tremendous spike in reports to poison control centers, with a 1,398% increase in such calls between 2012 and 2015 a trend that coincided with the increasing use of e-cigarettes in the United States in general, according to Alex Clark, CEO of Consumer Advocates for Smoke-Free Alternatives Association (CASAA), who tells Rolling Stone 2013 was the year vaping became more mainstream. In the years following, however, the number of calls starts to decrease significantly, with the rate decreasing 20 percent between 2015 and 2016

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The Food and Drug Administration has shown concern about Juul in the past E-cigarettes' detrimental health effects and rising popularity have lead the FDA to call out Juul, suggesting that the brand and other high-nicotine e-cigarettes have contributed to the teenage vaping epidemic, Business Insider previously reported

Furthermore, some cases of EVALI have shown that if left untreated, the condition can lead to irreversible lung injury

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