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Millennial and Gen Z media viewers are likely to associate O'Hara with her beloved late-career portrayal of the cartoonishly larger-than-life Moira Rose, a onetime actor who struggles to adjust to life as a former rich person on Schitts Creek. O'Hara was also a favorite ensemble performer of mockumentary pioneer Christopher Guest, and they teamed up in the cult classics Waiting for Guffman, Best in Show and A Mighty Wind. Her collaborations with director Tim Burton, as eccentric modern artist Delia Deetz in the "Beetlejuice" films and the voice of Sally in "The Nightmare Before Christmas," also earned her legions of fans

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An alternative treatment option was the intravitreal injection of Jetra (ocriplasmin, ThromboGenics), which produced proteolytic activity to the proteins at the interface to induce PVD