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That is the evidence gap, stated plainly: the mechanism is well-motivated and the preclinical signal is consistent, but no human study has confirmed that any of it translates to people, at any dose, by any route

Although rare, B12 can sometimes cause diarrhea, mild itching, or hives

[8] Early small-scale research suggested it may stimulate lipolysis (the breakdown of fat) and inhibit lipogenesis (fat storage), with preliminary data indicating it may not significantly affect blood glucose or insulin-like growth factor-1 (IGF-1) levels

A common extra is the initial consultation fee , which could add 25 to 50 to your first visit