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Abstract The STEP 5 trial assessed the efficacy and safety of once-weekly subcutaneous semaglutide 2.4 mg versus placebo (both plus behavioral intervention) for long-term treatment of adults with obesity, or overweight with at least one weight-related comorbidity, without diabetes

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Reversibility of weight loss associated with treatment with semaglutide

Cardiometabolic and Physical Health: Anecdotal studies suggest that it may have a positive influence on cardiometabolic and physical health

Clinical trials showed average weight loss of 5-8% of body weight with liraglutide 3.0mg daily, roughly half of what semaglutide or tirzepatide achieves