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A clinical trial involving 42 PD patients (2:1 randomized to NAC or control) demonstrated that a 3-month NAC regimen (50 mg/kg intravenous weekly plus 600 mg oral twice daily, skipping oral doses on infusion days) significantly increased dopamine transporter binding compared with the control group

10.1016/j.coph.2016.08.007 93

10.1093/pcp/pcr133 2 AstierJ.KulikA.KoenE.Besson-BardA.BourqueS.JeandrozS.et al

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RMT begins with ligand-receptor binding, which is quickly followed by receptor-mediated endocytosis, delivering the drug carrier attached to the ligand to a specific location