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p38 MAPK activity leads to enhanced production of type I collagen by myofibroblasts, a key event in the development of fibrosis in organs such as the liver and lungs

This can impair behavior, coordination, and judgment much faster

A: Yes, split dosing (0.5mg twice daily instead of 1mg once daily) maintains more stable plasma concentrations and may reduce peak-related side effects like headaches or overstimulation

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