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It is well documented that women often have a harder time with quitting smoking and do not respond as well to some nicotine replacement therapies, compared with men

Emphysema: Affects the air sacs (alveoli) in the lungs, causing shortness of breath, coughing, and extreme tiredness (fatigue)

McKenna, T.: Food of the Gods The Search for the Original Tree of Knowledge A Radical History of Plants, Drugs, and Human Evolution , Bantam Books, 1993, p

I know because I did it myself on January 10th, 1988

A good chunk of time is spent showing Billy the former prospect in flashback and Billy the divorcee (to Robin Wright) and father out of the office