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As for exploratory correlations, the inverse association between nadir CD4+ cell count and WB SUV indicates that a history of severe HIV infection results in greater neuroinflammatory processes (as previously proposed [72])

A period effect such as procedure fatigue, with an increasingly relaxed stance towards the rigid measurement protocol, could have affected our results

Among these mediators, TGF-1 is particularly significant, as it directly activates HSCs and stimulates the synthesis of extracellular matrix proteins, thereby promoting fibrogenesis

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