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In the prefrontal cortex, increased TDO and KMO expression alongside reduced IDO and KAT shifts metabolism toward QA production, while cerebellar KYNA levels inversely correlate with symptom severity, linking KP dysfunction to 5-HT metabolism and clinical features [235]
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Key accelerators include: Mitochondrial dysfunction: Leading to reduced energy output and increased reactive oxygen species (ROS)
Bee venom, immunostimulant or immunosuppressor
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