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Some other studies focus on the variations of genes within the context of tobacco smoking and detected the associations between smoke exposure and CTFR dysfunction [117, 118], which could in turn lead to deleterious effects on airway surface liquid secretion, enhanced mucus expression, reduced mucociliary clearance, chronic bacterial infection, and excess inflammation [119], rendering the main morbidity and mortality in CF patients because of the fact that lung inflammation and chronic respiratory infections alone account for nearly 95% of the morbidity and mortality in patients with CF [120]

Actor Andy Garcia puffs on a cigar at the 3M Celebrity Challenge in the prelude to the AT&T Pro Am at Pebble Beach, California on February 6, 2013

Retrieved 19 March 2018

Tax policies are also particularly effective on younger generations, who are more sensitive to the price argument, since the same increase reduces consumption among adolescents by 6 to 7%

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