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Pycnogenol, extracted from French maritime pine bark, has been shown to reduce fluid build-up and blood clots in people with a history of venous thrombosis

Reduced effectiveness despite consistent dosing can also indicate degradation, though this is harder to confirm objectively

Apart from red-colored urine (in case of intravenous administration), innocent skin discoloration, and possible soft stools, no side effects have been reported at the intervention evaluation

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Retinoids (retinol) and corticosteroids should be avoided for 1-2 weeks before and after treatment, to avoid over-stimulation of the skin as it prepares and recovers from the laser treatment