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Large studies have found varenicline to be effective and well tolerated: compared to those who received placebo, smokers who received varenicline while trying to quit were more than two and a half times more likely to be cigarette-free one year after entering the trial

However, nicotine, when administered through tobacco products, carries significant health risks including addiction, lung cancer, cardiovascular disease, and the like [16]

Reynolds finally ended the Joe Camel campaign in 1997 in the face of lawsuits, Congressional scrutiny, a Federal Trade Commission investigation and public outrage," health groups wrote

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