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In contrast to alcohol, cocaine intake increases the GLP-1 levels in the plasma in rodents (You et al., 2019) and reduces the corresponding levels in humans ( 4 Confounding factors Although the aforementioned studies show that GLP-1R agonists and/or GLP-1 modulate the responses to alcohol and addictive drugs, various limitations and confounding factors influence the conclusions that can be drawn from the acquired data