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Although there is no consensus regarding the increased activation of nicotinamide adenine dinucleotide phosphate oxidase by smoking, xanthine oxidase, an ROS-producing system, is activated by smoking

This can cause chest discomfort described as pressure, tightness, or heaviness

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Upon returning to England, Hariot wrote an account of the Virginia colony where he explained, "We ourselves during the time we were there used to suck it [tobacco] after their maner [using pipes], as also since our returne, & have found manie rare and wonderful experiments of the vertues thereof

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