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2) contraindication for the use of cytisine (hypersensitivity to the active ingredient or to any of the excipients including mannitol, microcrystalline cellulose, magnesium stearate, glycerol, cybehenate, hypromellose), unstable angina, recent history of myocardial infarction (previous 4 weeks), clinically relevant arrhythmias (previous 4 weeks), recent history of cerebrovascular accident (previous 4 weeks), and pregnancy and breastfeeding

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Commercial smuggling is a much larger operation and generally originates in tobacco states that have low excise taxes