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While clinical studies have not specifically evaluated its effects on estradiol levels or fertility markers, non-clinical repeat-dose toxicity studies in cynomolgus monkeys revealed reproductive system toxicities at high doses ( 60 mg/kg, approximately six times the recommended human dose), including endometrial atrophy and increased follicular atresia [157]

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While vitamin B12 is essential for many bodily functions, you may find that high doses can sometimes contribute to breakouts if your body is sensitive to it