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If syphilis is left untreated during pregnancy it can lead to early birth, low birth-weight, stillbirth, death shortly after birth or other sequelae in the baby, including inflammatory manifestations affecting the eyes, ears and joints, as well as skeletal malformations resulting from developmental damage during the early stages of syphilis

The present work is unrelated to the above grants and relationships.The other authors report no biomedical financial interests or potential non-financial competing interests

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The cotton workers cohort was much smaller with 1548 men and 1911 women but 900 and 1118 deaths before age 90