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A 2016 study by Fabbrocini et al 15 involved a double-blind, placebo-controlled, randomized clinical trial in 20 adult subjects to assess the efficacy of the oral probiotic Lactobacillus rhamnosus on acne and expression of insulin-like growth factor 1 (IGF-1) and forkhead box protein O1 (FoxO1)

Lancet 352 , 11721177 (1998)

Specifically, thiamine is important for glucose metabolism [51] and type 2 diabetics have been observed to have lower-than-average thiamine levels, suggesting that some degree of thiamine deficiency may play a role in the onset of diabetes

Bianchi P, Ciani E, Contestabile A, Guidi S, Bartesaghi R